As I mentioned in one of my previous posts
The performance optimization is a good topic for a separate blog and will not fit into one post BUT one of the things can be done pretty easily and give drastic performance improvements (2x and more times) for the content delivery side, also take the load of your SQL box. I am talking about database-level caching, particularly Item and Data caches.
If the values of "Size" column for web[data] and web[items] are approaching the "MaxSize" value, consider adjusting the values in web.config. There are no actual rules here 'cause the recommended values depend on your solution (content volume mostly). So by playing with the values, find the one that fits your needs. What will happen if your caches are maxed out? Nothing too exciting, actually. The next item information will trap into the cache but some lonely item will be evicted without two week notice.
You can find the description of cache settings , but in nutshell, there are multiple locations where you can specify cache sizes:
This is the order of processing. If any value greater than 0 is defined in a higher level, this value will be returned.
As for #3, it is important to note that some caches do not have the default cache values defined in the <settiings> section. This includes ChildCache, ParentCache and ItemCache. So if the search of the cache size falls down to #3, the value specified in code will be assigned.
As a part of the cache value assignment process, check this known issue
I also want to stress that same rules are applied to other database-level and website-level caching types.